LIG3 and adenoma: For each of the two LIG3 tagSNPs, among individuals with one copy of the minor allele, those with the highest level of dietary folate intake had a 31% and 37% decreased adenoma risk compared to those with the lowest level of dietary folate intake for LIG3 rs1052536 (OR = 0.61; 95%CI = 0.51–0.93; p = 0.015; p for trend = 0.021) and LIG3 rs3744358 (OR = 0.63; 95%CI = 0.45–0.90; p = 0.010; p for trend = 0.003), respectively.