When adenomas location (colon versus rectum), we observed two NEIL2 tagSNPs were associated with increased risk for rectal adenomas: NEIL2 rs7015453 (OR = 1.72; 95%CI = 1.24–2.39; PACT = 0.025; pheterogeneity = 0.003) and rs3757949 (OR = 1.58; 95%CI = 1.18–2.13; PACT = 0.044; pheterogeneity = 0.004) (Table 4). These two tagSNPs were not found to be in LD among NHW (r2 = 0.11), among whom we observed similar findings (data not shown). This evidence concerns the gene NEIL2 and rectum adenoma.