Using subjects with the hOGG1 Ser/Ser genotype as the reference group, homozygous carriers of the hOGG1 326Cys/Cys genotype had a 1.54-fold risk of lung adenocarcinoma compared with the homozygous wild genotypes (95% CI: 1.01–2.36, P = 0.045). This evidence concerns the gene OGG1 and lung adenocarcinoma.