Although the incidence of medulloblastoma appears higher in Ptch1+/− mice than Sufu+/− mice [36], [37], haploinsufficiency of SUFU in humans seemingly leads to a stronger predisposition to medulloblastoma [38] compared to haploinsufficiency of PTCH1, in which the patients develop medulloblastoma at less than 10% frequency [39]. Here, SUFU is linked to medulloblastoma.