SREBF1 and Familial prostate cancer: To investigate whether miRNAs regulate the SREBP-lipogenesis-cholesterogenesis metabolic pathway in prostate cancer cells, we first used TargetScanHuman 6.2 online software (http://www.targetscan.org/) to predict if one or more miRNAs target both SREBP-1 and SREBP-2, two key transcription factors that regulate fatty acid, lipid and cholesterol biosynthesis and homeostasis.