Both miR-185 and 342 inhibited the expression of mRNAs (Fig. 1A) as well as precursor (125 kDa) and mature (68 kDa) proteins (Fig. 1B) of SREBP-1 and SREBP-2 in LNCaP and C4-2B prostate cancer cells. This evidence concerns the gene SREBF1 and prostate cancer.