Akita mice also demonstrated hyperlipidemia, elevated PAI-1 and attenuated body mass accrual by 6 weeks of untreated diabetes (Table 1), consistent with observations of T1DM in humans [20], [34], [35] and diabetic rodents [2], [21], [22], [31], [36], [37]. This evidence concerns the gene SERPINE1 and diabetes mellitus.