The activity of plasminogen activators (PA), such as urokinase PA (uPA), are requisite for skeletal muscle regeneration [15]–[19], but PA activity is limited by plasminogen activator inhibitor-1 (PAI-1), a diurnally regulated hormone that is significantly and chronically elevated in both type 1 and type 2 diabetes [2], [20]–[22]. The gene discussed is SERPINE1; the disease is type 2 diabetes mellitus.