Low levels of calpastatin expression in the brain compared to other tissues [32] and a lack of CAST deregulation in SN neurons obtained from post-mortem PD nerve tissue by laser-capture dissection compared to controls [33] argues against the idea that calcium-dependent protease calpain inhibitor calpastatin plays a significant role in the regulation of dopaminergic cell death. The gene discussed is CAST; the disease is Parkinson disease.