To date, four genes, myocilin (MYOC)[13], neurotrohin 4 (NTF4)[14], optineurin (OPTN)[15] and WD repeat domain 36 (WDR36)[16] and at least 20 genetic loci of which 14 are named (GLC1A-N) [17], [18] have been associated with human POAG. The gene discussed is OPTN; the disease is open-angle glaucoma.