We had to use high concentration of SB303580 to block IL-1α and as this inhibitor is known to also work on other MAPKs at high concentration did we confirm the role of p38MAPK in the regulation of tumor cell associated IL-1α by using SB220025, which is considered to be a very specific inhibitor of p38 MAPK than SB203580. Here, IL1A is linked to neoplasm.