After adjusting for a history of CVD, current smoking, hsCRP, HDL, TNF-α, and IL-1β levels, age (P<0.001), male (P<0.001), diabetes (P = 0.048), hypertension (P = 0.031), a history of CKD (P = 0.047), hyperuricemia (P = 0.001), and IL-6 levels (P = 0.038) were independent risk factors for eGFR <60 mL/min/1.73 m2. The gene discussed is TNF; the disease is hypertensive disorder.