After adjusting for age, hyperlipidemia, BMI, triglyceride and LDL levels, female (P = 0.013), diabetes (P<0.001), hypertension (P = 0.045), a history of CKD (P = 0.011), hyperuricemia (P = 0.025), hyper-cholesterol (P = 0.037), hsCRP (P = 0.033) and TNF-α levels (P = 0.028) were independently associated with an increased risk of albuminuria. The gene discussed is TNF; the disease is hypertensive disorder.