TMEM18 and obesity due to melanocortin 4 receptor deficiency: However, in adults the MC4R rs17782313 obesity-risk allele was associated with increased glucose levels (Padd  = 0.034), TMEM18 rs6548238 and FTO rs9939609 were associated with lower fasting insulin levels (Padd  = 0.013 and 0.050, respectively), while FTO was associated with lower triglyceride levels (Padd  = 0.048) and BDNF was associated with higher triglyceride levels (Prec  = 0.047) In children, only INSIG2 and BDNF were significantly associated with higher and lower triglyceride levels (Padd  = 0.004 and Prec  = 0.006, respectively).