UCP3 and obesity due to melanocortin 4 receptor deficiency: ADIPOQ rs2241766 showed a nominal significant association with overall obesity (OR 2.34, Prec  = 0.033, recessive model), and UCP3 rs1800849 was significantly associated only with class I/II obesity (OR 1.33, Padd  = 0.050, additive model; Table 1).