On the other hand, 5 of the 17 SNPs previously identified as obesity risk alleles by GWAS showed overall significant associations with obesity in the Mexican population (Table 1): FTO rs9939609 (OR 1.42, Padd  = 0.001), TMEM18 rs6548238 (OR 1.57, Padd  = 0.003), INSIG2 rs7566605 (OR 1.33 Padd  = 0.006), FAIM2/BCDIN3 rs7138803 (OR 1.88, Prec  = 0.034), and BDNF rs6265 (OR 1.33 Prec  = 0.044). The gene discussed is TMEM18; the disease is obesity due to melanocortin 4 receptor deficiency.