Using a case control design, we sought to assess the contribution of two different sets of SNPs with obesity in Mexican Mestizo adults: 9 SNPs in biological candidate genes showing replications in at least 10 studies (PPARG, ADRB3, ADRB2, LEPR, GNB3, UCP3, ADIPOQ, UCP2, and NR3C1) [5] and 17 SNPs in or near genes associated with obesity in first, second and third wave GWAS (INSIG2, FTO, MC4R, TMEM18, FAIM2/BCDIN3, BDNF, SH2B1, GNPDA2, NEGR1, KCTD15, SEC16B/RASAL2, NPC1, SFRF10/ETV5, MAF, PRL, MTCH2, and PTER) [12]–[18]. This evidence concerns the gene MC4R and obesity due to melanocortin 4 receptor deficiency.