CTGF mediates induction of genes for various extracellular proteins including thrombospondin I (TSP1) in bleomycin induced pulmonary fibrosis, plasminogen activator inhibitor type 1 (PAI-1) and collagen I, III and IV in rat kidney fibroblasts [39]–[41]. The gene discussed is THBS1; the disease is pulmonary fibrosis.