Our present study demonstrated that PDGFR-β, as a cell surface mechanoreceptor, conveys mechanical signals to intracellular sensors to produce MMP-2 via regulation of Akt activity in VSMC exposed to MS, suggesting that PDGFR-β/Akt signaling axis might play a pivotal role in vascular remodeling induced by mechanical stress linked to arterial hypertension. Here, AKT1 is linked to Hypertension.