FTO and obesity due to melanocortin 4 receptor deficiency: The results of GWAS imply that with few exceptions (eg FTO [51]) T2DM susceptibility is inherited independently of obesity susceptibility and under those conditions, and assuming a heterogenetic model of T2DM genetics, approximately 30% (0.59×0.5) of our population of FH+ would be at high risk of developing T2DM in their current environment.