From the biological point of view, the expression patterns of ACE2, FLOT1 and PRKD1 in association with good or bad prognosis are largely in line with the proposed anti-growth and anti-tumor roles for ACE2 [48], ; with tumor promoting roles for FLOT1 [50], [51]; and, with pro-metastatic roles for PRKD1 [52], [53], [54]. This evidence concerns the gene FLOT1 and neoplasm.