Pathway analysis of the 18-target list revealed three canonical pathways enriched with differentially-expressed and differentially-methylated genes in naïve DC: the Jak-Stat pathway, which is mostly down-regulated in asthma-at-risk DC (and remains significant even if only down-regulated genes are analyzed), the RAR-alpha pathway (Fig. 2), and a cluster of genes in the VEGF pathway. The gene discussed is SOAT1; the disease is asthma.