Indicating the negative cognitive effects of ACK treatment, we found the significant population of neurodegenerative disease pathways (Alzheimer’s, Parkinson’s and Huntington’s disease), neurodevelopmental effects (long-term potentiation, neurotrophin signaling pathway, Wnt signaling pathway and axon guidance) and signaling paradigms associated with excitoxicity (calcium signaling pathway, apoptosis and MAPK signaling). Here, BDNF is linked to Huntington disease.