Indicating the negative cognitive effects of ACK treatment, we found the significant population of neurodegenerative disease pathways (Alzheimer’s, Parkinson’s and Huntington’s disease), neurodevelopmental effects (long-term potentiation, neurotrophin signaling pathway, Wnt signaling pathway and axon guidance) and signaling paradigms associated with excitoxicity (calcium signaling pathway, apoptosis and MAPK signaling). The gene discussed is TNK2; the disease is Huntington disease.