HPCA and Cognitive impairment: Underpinning these functional predictions at the individual transcript level were multiple genes closely related to energy regulation (Ckb, Atp5B, Aldoc, Eno2, Ndufa13, Ndufb4: [54]–[59], cognitive-impairment associated neurodegeneration (Stxbp1, Itm2b, Cdk5r1, Ppp3ca, Hpca: [60]–[64] and neurotrophin/synaptic functionality (Elavl4, Ndrg4, Camk2b, Stmn1, Wasf1: [65]–[69].