Overexpression of these genes was shown in other cancers, for instance higher expression of GPM6B was associated with brain tumors [13], [14] and lymphoid leukemias [15], MAGEA12 was up-regulated in bladder carcinoma [16], melanoma [17], breast cancer [18] and oral squamous cell carcinoma [19], whereas FCRL1 induction was observed in metastatic melanomas [21] and in different types of leukemias [20]. The gene discussed is GPM6B; the disease is oral cavity squamous cell carcinoma.