GPM6B and hepatocellular carcinoma: The GPM6B probe which differentiated all HCC from NorAdjRef in the Shanghai group of patients also showed different melting patterns in HCC and CHB except one patient with HCC who was grouped together with CHB based on melting peak temperature (Table 3, Figure 4A, P = 0.028, adjusted P = 0.084, Mann-Whitney U test; P<0.0001, permutation test).