Fifth, the genes were previously associated with human cancers, in particular MAGEA12[16], [17], [18], [19] however only DISCS LARGE (DROSOPHILA) HOMOLOG-ASSOCIATED PROTEIN 5 (DLGAP5) and MATRIX METALLOPEPTIDASE 1 (MMP1) have been previously reported to be up-regulated in HCC tumors [26], [27]. This evidence concerns the gene MMP1 and hepatocellular carcinoma.