ANXA2 and hepatocellular carcinoma: These results showed that ANXA2 and CD147 co-immunoprecipitated with each other in the TMP extracted from both SMMC-7721 and FHCC-98 cells (Fig. 3C), indicating that ANXA2 and CD147 co-localize on HCC membrane, and there may be interaction effects due to membrane-associated events between the two molecules.