Based on the involvement of ANXA2 in exocytosis and membrane vesicle trafficking [4], [5] and the role of CD147-harboring membrane microvesicles on tumor progression, we hypothesized that ANXA2 is involved in the shedding of CD147-harboring microvesicles from tumor cells, thereby regulating tumor migration and invasion. The gene discussed is BSG; the disease is neoplasm.