The characterization of TILs polarization in PDAC was initially reported in (Tassi et al., 2008), in which the presence of Th2, Th1 and Tregs cells in tumor samples was evaluated by immunohistochemistry using specific antibodies for GATA-3 (i.e., to detect Th2 cells), T-bet (i.e., to detect Th1 cells) and FoxP3. Here, FOXP3 is linked to neoplasm.