Remarkably, of the 63 CpGs in T-cells, 58 CpGs in B-cells, and 23 CpGs in monocytes that had highly significant changes in methylation (p < 1×10−8) near an interferon type-I regulated gene, only 1 CpG in B-cells, located at the 3′ end of STAT3, was hypermethylated in SLE patients. The gene discussed is STAT3; the disease is systemic lupus erythematosus.