TNFSF13 and infection: This construct inhibits the TNFSF13 region that is also required to generate TNFSF12-TNFSF13 that arises as a fusion protein derived from TNFSF12 and TNFSF13.24 Silencing of these proteins resulted in full protection of A549 cells from the cytotoxic effects of infection with influenza virus strains NY55, PR8 or SOIV (Figure 4).