Accordingly, it has been shown that the presence of cytotoxic CD8 T cells within the CTCL lesions is a positive prognostic factor, and several case reports have evidenced that use of the immunosuppressant cyclosporine in treatment of CTCL accelerates disease progression and large cell transformation [10,29,30]. The gene discussed is CD8A; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.