Results of multivariate logistic regression analysis (Table 2) indicate that central ACE inhibitor use (OR = 0.85, 95% CI = 0.74, 0.98, p = 0.03) or peripheral ACE inhibitor use (OR = 0.68, 95% CI = 0.54, 0.86, p = 0.001) was inversely associated with a risk of developing AD dementia after adjusting for ApoE4 and other confounders including age, gender, ethnicity, education, smoking, drinking, and the follow-up time (Model I). This evidence concerns the gene ACE and Alzheimer disease.