Again, both central ACE inhibitor use (OR = 0.68, 95% CI = 0.55, 0.83, p = 0.0002) and peripheral ACE inhibitor use (OR = 0.46, 95% CI = 0.32, 0.66, p < 0.0001) were inversely associated with the development of AD in the absence of ApoE4. This evidence concerns the gene APOE and Alzheimer disease.