Adding the variables of vascular diseases including diabetes, hypertension, stroke, and heart failure in addition to amnestic MCI and non-amnestic MCI to this model did not affect the relationship between either central ACE inhibitor use (OR = 0.79, 95% CI = 0.67, 0.93, p = 0.004) or peripheral ACE inhibitor use (OR = 0.73, 95% CI = 0.57, 0.94, p = 0.02) and a risk of developing AD (Model II). The gene discussed is ACE; the disease is Stroke.