APOE and alcohol abuse: ApoE4 non-carriers were older (mean ± SD: 77.3 ± 8.1 versus 74.6 ± 7.1, p < 0.0001), had longer follow-up time (mean ± SD: 3.5 ± 1.1 versus 3.3 ± 1.2, p < 0.0001), were more likely to report current smoking (χ2 test: 4% versus 3%, p = 0.01) and alcohol abuse (χ2 test: 5% versus 3%, p = 0.01) than ApoE4 carriers.