Thus it is an essential sensor and activator of cell cycle initiation and progression; Cyclin D1 amplification and gain copies with consequent protein over-expression have been frequently described in multiple myeloma, T cutaneous lymphomas and in solid cancer[18], such as oral squamous cell carcinoma, lung cancer, melanoma, breast cancer[19,20]. This evidence concerns the gene CCND1 and oral cavity squamous cell carcinoma.