In order to provide further insight into the response to hypoxia in main components of the tumor microenvironment like CAFs, we began our study showing that hypoxia induces the mRNA expression of both HIF-1α and its target gene GPER, as ascertained by real time PCR (Figure 1) and semi-quantitative PCR (data not shown). The gene discussed is HIF1A; the disease is neoplasm.