Further review of the list of genes harboring variants not found in public databases and predicted to be damaging to protein function failed to identify any genes that have been annotated as part of the mitochondrial proteome, but did reveal an additional missense variant in the known disease gene, OCRL. Mutations in OCRL cause Lowe Syndrome as well as Dent2 disease. This evidence concerns the gene OCRL and oculocerebrorenal syndrome.