B7-H3 (CD276) is a member of the B7 family and is expressed by lymphoid cells, such as dendritic cells, monocytes/macrophages and activated T cells; non-lymphoid tissue cells express B7-H3 too, such as epithelial cells, anterior pituitary progenitor cells, muscle cells and fibroblast-like synoviocytes [6,7], B7-H3 was reported expressed in non-small cell lung cancer, prostate cancer, neuroblastoma and renal cell carcinoma [8-10]. Here, CD276 is linked to renal cell carcinoma.