Nasal priming with lactobacilli resulted in marked suppression of IFN-inducible protein-10 (CXCL10), MCP-1 (CCL2), neutrophil-activating protein-3 (CXCL1), MIP-1γ (CCL9), TNF, and eotaxin-2 (CCL24) in response to pneumovirus infection and significantly increased the resistance against the lethal disease. Here, CXCL10 is linked to Pneumovirus Infections.