SERPINE2 and obesity due to melanocortin 4 receptor deficiency: In fact, obesity in humans is described as chronic low-grade inflammation where expression of hemostatic genes [e.g., serine peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (PAI-1), thrombin, fibrinogen and von Willebrand factor (VWF)] are positively associated with greater deposition of adipose tissue [47,51].