Likewise, it will be important to understand further the role of IL-15 in the progression of CIN advancing to cervical cancer, as this cytokine has also, paradoxically, been implicated in cervical cancer immune escape through its role in the over-expression of the inhibitory receptor CD94/NKG2A on tumor-infiltrating CD8+ T lymphocytes[58]. The gene discussed is CD8A; the disease is cervical squamous intraepithelial neoplasia.