DNMT3A mutations and deletions have been analyzed in AML (5), chronic myeloid leukemia (CML), chronic myelomonocytic leukemia (CMML), myelodysplastic syndrome (MDS), lymphoma and myeloproliferative neoplasms (MPNs) (6–11). The gene discussed is DNMT3A; the disease is acute myeloid leukemia.