DNMT3A mutations and deletions have been analyzed in AML (5), chronic myeloid leukemia (CML), chronic myelomonocytic leukemia (CMML), myelodysplastic syndrome (MDS), lymphoma and myeloproliferative neoplasms (MPNs) (6–11). This evidence concerns the gene DNMT3A and myeloproliferative neoplasm.