However, to better understand the regulation of D6 in a chemotactic network in human tumors, further investigation with regard to the regulation of D6 expression in tumors, D6 expression as a prognostic factor in lung cancer patients, the effects of D6 on sensitivity to chemotherapy and targeted therapy and the potential of D6 as a new therapeutic avenue for cancer treatment is required. This evidence concerns the gene ACKR2 and lung cancer.