Considering that D6 functions as a decoy receptor by clearing these ligands, we hypothesized that D6 may also be involved in tumor progression by regulating chemokine levels, and existing studies have confirmed this hypothesis; Nibbs et al observed that D6 inhibits chemically induced skin de novo tumorigenesis via sequestration of inflammatory CC chemokines (14). This evidence concerns the gene ACKR2 and neoplasm.