Therefore, we may deduce that TERT acts as a transcription factor to modulate the expression of c-Fos and c-Jun, as the expression of TERT is closely correlated with c-Fos and c-Jun mRNA and protein expression in HEp-2 laryngeal carcinoma cells, and is positively correlated with c-Fos and c-Jun mRNA expression in human laryngeal carcinoma tissues. This evidence concerns the gene FOS and laryngeal carcinoma.