Jacobs et al (22) analyzed cancer-germline gene expression, including that of MAGE-A1, -A2, -A3, -A4, -A6, -A10, -A12 and -C2, NY-ESO-1 and GAGE-1, 2 and 8 in 50 pediatric brain tumors (including 36 gliomas) using real-time PCR, and noted that 67% of astrocytic tumors expressed one or more cancer-germline genes. The gene discussed is GAGE1; the disease is cancer.