Using an immunohistochemistry assay with anti-SD that recognizes the ZNF268a and ZNF268b2 isoforms (6) the present results demonstrated that total ZNF268 protein was overexpressed in ovarian cancer and that ZNF268 (ZNF268a/ZNF268b2)-knockdown increases the growth of SKOV-3 cells. This evidence concerns the gene ZNF268 and ovarian cancer.