To further understand whether the functions of TLR2 and TLR3 in the PBMCs of patients with wet AMD are altered, we measured the concentration of IL-6, IL-8, MCP-1, and VEGF in the supernatants of PBMCs after stimulation with their ligands, PGN and poly(I:C). This evidence concerns the gene TLR3 and wet macular degeneration.