α- and γ-MG decreased expression of IL-6, TNF-α, IFN-γ-inducible protein (IP)-10 in macrophage-like cells; decreased phosphorylation of MEK, JNK, ERK and p38; only γ-MG pretreatment attenuated LPS-mediated IκBα degradation; α- and γ-MG pretreatment decreased phosphorylation of c-Jun, Elk-1 and ATF-2; α- and γ-MG attenuated LPS-induced PPAR-γ suppression; γ-MG reduced inflammation and insulin resistance in adipocytes. Here, MAP2K7 is linked to Insulin resistance.