IGF2 and male reproductive organ cancer: Elevated EGR1 in esophageal cancer plays an important role in mediating and maintaining growth-related oncogene/CXC chemokine receptor 2 proliferative signaling[34].EGR1 is overexpressed in primary human prostate carcinomas [36, 37], and several EGR1 target genes (e.g. insulin-like growth factor II, transforming growth factor β1, and platelet-derived growth factor A-chain) have been implicated in prostate tumorigenesis [37].