ACE and ventilator-associated pneumonia: ACEI, angiotensin converter enzyme inhibitor; AKI, acute kidney injury as defined per RIFLE criteria; BMI, body mass index; BSI, bloodstream infection; CMS, colistin methanesulfonate sodium; CRRT, continuous renal replacement therapy; CVC, central venous catheter; NSAID, nonsteroidal anti-inflammatory drug; Pts, patients; SAPS II, simplified acute physiology score two (calculated 24 h after ICU admission); VAP, ventilator-associated pneumonia.