The putative role of NET1 in epithelial mesenchymal transition via TGF-β [13,14,19,30] and the significance of this concept in OAC, coupled with the data presented here, strengthen the hypothesis that NET1 plays an important role in the tumour biology of oesophageal adenocarcinoma. Here, TGFB1 is linked to esophageal adenocarcinoma.