Recognising the mounting cellular and molecular evidence for a role for NET1 in mediating gastrointestinal (GI) cancers and coupled with the phenotypic similarities recognised in the pathogenesis of gastric and oesophageal adenocarcinomas [1], we sought to investigate and fully characterise the bioactivity of NET 1 in oesophageal cancer. The gene discussed is NET1; the disease is carcinoma of esophagus.