A previous report showed that DAAP was highly effective for suppressing tumor angiogenesis and metastasis in implanted and spontaneous solid tumors, as well as for reducing ascites formation and vascular leakage in an ovarian carcinoma model, compared with VEGF-Trap or Tie2-Fc, which block only VEGF or angiopoietin signaling, respectively [22]. The gene discussed is VEGFA; the disease is neoplasm.