RABGEF1 and neoplasm: RABEX-5 expression was associated with tumor size and axillary lymph node metastases (P<0.05) (Table 1, Figure 1D) but not with age, grade, and ER, PR, and C-erBb-2 status (P>0.05), suggesting that there is a relationship between RABEX-5 overexpression and breast cancer metastasis.