In addition, the expression of HCC invasion/metastasis-associated genes (MMP2, MMP9, OPN, and CD44) in the subcutaneous mixed tumor of MHCC97H cells and HUVECs were significantly higher than those formed by MHCC97H cells alone (*p < 0.05; Figure 1B). This evidence concerns the gene MMP2 and hepatocellular carcinoma.