Among the events that we predicted are several known to be important in AML: a PTD in the myeloid/lymphoid or mixed-lineage leukemia (MLL) gene[3]; two distinct ITDs in the fms-related tyrosine kinase 3 (FLT3) gene[4]; and a pair of reciprocal fusions between the promyelocytic leukemia (PML) and alpha retinoic acid receptor (RARA) genes[2]. Here, PML is linked to acute myeloid leukemia.