In addition, positional cloning technique reveals that the mutations in SETX gene in the locus also associated with autosomal recessive spinocerebellar ataxia-1 (SCAR1), which is also referred to ataxia-ocular apraxia-2 (AOA2)[19]. The gene discussed is SETX; the disease is Spinocerebellar ataxia with axonal neuropathy type 2.