CASP9 and neuroblastoma: LCA selectively initiates an extrinsic apoptotic programme of cell death in neuroblastoma cells, thus recruiting and activating the initiator caspase-8, inducing mitochondrial outer membrane permeabilization (MOMP), mitochondrial fragmentation, and ultimately activation of the downstream proteases caspase-9 and -3 (Goldberg et al., 2011).