CASP3 and Familial prostate cancer: Our findings in this report share several similarities with those we described previously in neuroblastoma cells treated with LCA (Goldberg et al., 2011): (1) LCA elicits apoptosis in a caspase-3 dependent manner, (2) LCA activates both extrinsic and intrinsic pathways of apoptosis and (3) LCA enters neither neuroblastoma nor prostate cancer cells.