The inability of LCA and UDCA to enter LNCaP or PC-3 cells would suggest they would have equal opportunity to interact with a cell surface membrane receptor in order to induce apoptosis, yet LCA was far more potent than UDCA, supporting the notion that a specific interaction between LCA and a cell surface receptor, possibly TGR5, could be the event responsible for the apoptotic death of prostate cancer cells. This evidence concerns the gene GPBAR1 and prostate carcinoma.