For instance, nine of our candidate cancer genes were also contained in the Cancer Gene Census list, which comprises 487 genes causally linked to cancer [11], representing a highly significant enrichment (Abl2, Braf, Fbxw7, Foxp1, Ipo11, Mllt3, Fas, Pten, and Nf1; p<0.0002, Fisher’s exact test). This evidence concerns the gene FBXW7 and cancer.