The third eSNP gene, SPRYD7, (SPRY domain containing 7/chromosome 13 open reading frame 1 [C13or1]) also known as chronic lymphocytic deletion region gene 6 protein, (CLLD6) [32], is proposed to have a tumour suppressor function because it has been detected to be downregulated in B-CLL patients [33]. This evidence concerns the gene SPRYD7 and neoplasm.