PLAU and cervical carcinoma: Among all kinases tested, p38 MAPK phosphorylation was selectively and dramatically decreased in a dose-dependent manner without altering its protein amount in both SiHa and CaSki cells (Figure 3A), whereas the phosphorylation of ERK1/2 (Figure 3B), JNK1/2 (Figure 3C), and AKT (Figure 3D) showed no significant change, indicating that fisetin might repress the expression of uPA and reduce the migration and invasion of cervical cancer cells by inactivating the p38 MAPK pathway.