CASP3 and hepatocellular carcinoma: Fisetin induces apoptosis in various cancer cells through different mechanisms, it inhibits COX2 and Wnt/EGFR/NF-κB in HT-29 human colon cancer cells [24] and activates caspase-3 cascade in SK-HEP-1 hepatocellular carcinoma cells [20] and caspase-3 and Ca2+-dependent endonuclease in HL-60 human promyeloleukemic cells [11].