In this large, ethnic specific single institutional case-control study, we investigated the associations between six potentially functional SNPs of the mTOR gene and PCa risk, and we found that the rs2536 C, rs1034528 C, and rs2295080 G variant genotypes were associated with PCa risk, and the effects were more evident in subgroups of age≤69, BMI≤24 kg/m2, and ever-smokers. This evidence concerns the gene MTOR and posterior cortical atrophy.